Personalized therapy in pediatric nephrology: Problems and prospects
نویسندگان
چکیده
The term “personalized medicine” appeared only 20 years ago, but individual approaches to the therapy were known for more than a hundred years. genome decoding and development of pharmacogenetics in recent decades have opened up new ways medicine understanding concept medicine”. article uses example nephrological diseases (Denis–Drash syndrome, Freiser hypophosphatemic rickets, nephrotic syndrome) demonstrate importance molecular genetic examination improve effectiveness treatment and, most importantly, prevent iatrogenic side effects therapy. glucocorticoid children with syndrome is used studying certain factors that affect pharmacodynamic pharmacokinetic profile glucocorticosteroids.
منابع مشابه
Pediatric Nephrology
This is a multi-authored text which is meant as a comprehensive survey of clinical renal disease, basic mechanisms of renal function and immunopathology, as well as providing special consideration of these different aspects of nephrology as they relate to children. Since there is significant redundancy and uneveness throughout the text, the general format is more that of a series of essays than...
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Edited by Edited by Ellis D. Avner, Former President, American Society of Pediatric Nephrology, William E. Harmon from Harvard University, and Patrick Niaudet, Former President of the European Society of Pediatric Nephrology, Pediatric Nephrology (5th edition, LWW, 2004), this internationally focused book offers an overview of the anatomy, physiology, and biology of the pediatric kidney and foc...
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Idiopathic nephrotic syndrome is the most common type of nephrotic syndrome in children and is often associated with life threatening bacterial infections. While the majority of children respond to prednisolone, most have one or more relapses. In children with significant adverse effects of prednisolone, corticosteroid sparing agents may be required. A kidney biopsy is required to guide therapy...
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Pediatric nephrology is rapidly evolving. Over the last few decades we have witnessed a rapid change in nosology, etiology, pathogenesis and treatment of renal disease. We have seen advances in renal and urinary tract imaging as well as more precise use of novel urinary biomarkers to define the type and degree of renal injury, both acute and chronic. We now have better understanding of factors ...
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ژورنال
عنوان ژورنال: ?????????? ??????? ????????????? ? ?????????
سال: 2021
ISSN: ['2500-2228', '1027-4065']
DOI: https://doi.org/10.21508/1027-4065-2021-66-2-6-12